About

We are unlocking the regulatory genome to reveal the molecular drivers of immune-mediated disease using the unrivalled precision and scale of our 3D genomics technology, to forge a new era of transformative therapeutics. With an initial focus on inflammatory diseases, our technology is applicable to any disease with a genetic basis.

By decoding the molecular basis of disease directly in human cells – rather than relying on traditional animal models – Nucleome leverages naturally occurring non-coding variants to uncover causal molecular drivers of disease and novel drug targets. Our proprietary platform blends multi-dimensional 3D genomics at base-pair resolution with advanced machine learning to reveal, interpret and map at scale how these variants regulate gene expression across immune cell types. This enables precise characterisation of the molecular mechanisms and pathways of diseases. We have built a rich data atlas of hundreds of dysregulated genes across four major inflammatory diseases, establishing a bold new path to deliver antibody therapeutics for immune-mediated inflammatory diseases.

Science

World-Class Science

With science at the heart of what we do, we have an incredible team of scientists who are experts in their field from genetics to antibodies to CRISPR and laboratory skills, with the ability to draw on the complementary expertise and support of highly respected industry leaders, including:

  • Our founders at Oxford University – Prof. Jim Hughes and Prof. James Davies
  • Experienced Board members from premier pharmaceutical companies – Pfizer, Johnson & Johnson Innovations and Merck
  • Expert advisors across the full spectrum of Nucleome’s activities
  • Oxford institutions including Weatherall Institute of Molecular Medicine
  • The Oxford network
Science

Leadership

Leadership Team

Dr. Mark Bodmer

Dr. Mark Bodmer

Chief Executive Officer

Bhavna Hunjan

Bhavna Hunjan

Chief Business Officer

Dr. Jonny Wray

Dr. Jonny Wray

Chief Technology Officer

Dr. Michelle Morrow

Dr. Michelle Morrow

Chief Scientific Officer

Stephanie Maley

Stephanie Maley

Chief People Officer

Emma Morton, FCA

Emma Morton, FCA

VP, Finance

Board of Directors

Dr. Rana Al-Hallaq

Dr. Rana Al-Hallaq

Non-Executive Director

Dr. Bauke Anninga

Dr. Bauke Anninga

Non-Executive Director

Dr. Mark Bodmer

Dr. Mark Bodmer

Chief Executive Officer

Dr. John Davis

Dr. John Davis

Non-Executive Director

Dr. Russell Greig

Dr. Russell Greig

Non-Executive Chair of the Board

Dr. Jonathan Hepple

Dr. Jonathan Hepple

Non-Executive Director & OSE Advisor

Prof. Jim Hughes

Prof. Jim Hughes

Scientific Founder, Non-Executive Director

Dr. Nadiya Ishnazarova

Dr. Nadiya Ishnazarova

Non-Executive Director

Mark Wyatt

Mark Wyatt

Non-Executive Director

Investors

Nucleome is backed by world-class investors

Syndicate includes M Ventures, the strategic corporate venture capital arm of Merck KGaA; Johnson and Johnson Innovation-JJDC, Inc. (“JJDC”), the strategic venture capital arm of Johnson & Johnson; Pfizer Ventures, the venture group of Pfizer; the British Business Bank; and founding investor Oxford Science Enterprises.

Partnering

Nucleome is collaborating with a major pharmaceutical company and foresees multiple opportunities to collaborate with other companies to identify targets and responsive patients in a variety of therapeutic areas. Contact us and learn more.

Contact Us