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Scientist - Drug Discovery - Target Validation

COMPENSATION: Competitive with share options available

LOCATION: The Schrodinger Building, Oxford Science Park, Oxford

HOURS: Full-time


NUCLEOME THERAPEUTICS, a fast-emerging biopharma that is building a passionate, creative, and dedicated multi-disciplinary team of scientists with expertise in gene regulation, genomics, machine learning, drug discovery, data analysis and software development, whose mission is to decode and mine the regulatory “dark matter” of the human genome to transform drug target discovery and deliver first-in-class precision medicine for autoimmune diseases. We are building a rewarding and fun environment where people embrace creative ways of thinking, take smart risks, and feel empowered to make a difference.

The Role

The drug discovery team are looking for an innovative and talented scientist with an interest in drug target biology to support the biological validation of novel drug targets that emerge from Nucleome’s proprietary platform technology. In this lab-based role you will generate biological validation data packages to support the progression of drug targets into the company drug discovery pipeline. You will build cellular disease models to test therapeutic hypotheses, investigate the biology of novel drug targets, and characterise potential drug molecules in cellular assays. You’ll work with a variety of different immune cell types and have the opportunity to broaden your expertise and understanding of immunology, drug discovery and autoimmune disease. In your position you will work in close collaboration with other scientists across cross-functional teams and will have responsibility for delivery of defined biological validation studies. You will achieve visibility for your work by frequent presentation across team meetings and collaborative interactions.

What we are looking for

Essential knowledge
  • Good understanding of the principles of cell biology and cell signalling, ideally with some experience from an immune disease therapeutic area.
  • Understanding of principles of cellular assay optimisation with the aim of ensuring required reproducibility and sensitivity in those assays
  • Ability to design, execute and analyse cell and molecular biology experiments independently.
  • Ability to interpret, summarise and communicate results and ideas effectively across multi-disciplinary teams
Essential Skills and Experience
  • PhD level qualification or equivalent experience in a biological or pharmacological science
  • Recent experience in a cell biology role in an industrial biopharmaceutical setting
  • Direct practical cell and molecular biology experience including techniques such as (e.g., Flow cytometry/FACS; qRT-PCR, ELISA; plate-based fluorescence assays).
  • Track record for independently delivering high quality experimental results
  • Experience of analysing and presenting data and conclusions at project team and functional team meetings
Preferred experience
  • Research experience in immunological disease setting.
  • Primary cell culture and/or co-culture/ex vivo systems
  • Experience in CRISPR/RNAi technology
  • Experience in Immunohistochemistry (IHC) and/or in situ hybridisation (ISH)
  • Experience in cell culture imaging
To apply please send us your CV at [email protected]. If you know someone who could be a good fit, please share this posting with them.
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At Nucleome Therapeutics equality, diversity and inclusion is really important to us. We welcome applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status.