Skip to main content

Team Leader - Functional Genomics (Genomics Assay Development)

COMPENSATION: Competitive with share options available

LOCATION: The Schrodinger Building, Oxford Science Park, Oxford

HOURS: Full-time


NUCLEOME THERAPEUTICS, a fast-emerging biopharma that is building a passionate, creative, and dedicated multi-disciplinary team of scientists with expertise in gene regulation, genomics, machine learning, drug discovery, data analysis and software development, whose mission is to decode and mine the regulatory “dark matter” of the human genome to transform drug target discovery and deliver first-in-class precision medicine for autoimmune diseases. We are building a rewarding and fun environment where people embrace creative ways of thinking, take smart risks, and feel empowered to make a difference.

The Role

We are seeking a highly motivated and innovative Team Lead with expertise in Genomics Assay Development, a self-starter, who would thrive in the dynamic environment of a growing biotechnology company. The position has a strong focus on team management and leadership, and the successful candidate will be responsible for development and implementation of state-of-the-art genomics techniques, including NGS and other Omics techniques. You will use your extensive experience in people management to build, lead, and develop a high-performing team of scientists with expertise in genomic. You will manage all aspects of their performance management, objective setting, recruitment, and career development; as well as inspire and motivate them to excel. In your genomics assay development function, you will lead the design and implementation of new, cutting-edge genomics technologies in the field of 3D genomics, DNA, RNA, open chromatin, and epigenetics. Working within matrix team you will provide expertise, team leadership and support into discovery and validation of novel therapeutic targets and cell type mapping efforts. You will play a role in our interactions with both Industry Partners and Contract Research Organisations, and a role model to scientists within the team and across the company, motivating team members to realise their full potential. As an independent thinker you will plan and implement experiments, interpret the data, and distil complexity into concise communication. Working in a rapidly growing company, you’ll need a flexible mindset, with the ability to continually adapt to new challenges. You will be part of an interdisciplinary team and closely collaborate with computational and drug-discovery scientists to guide drug target discovery efforts. You will have an integral role in the venture, take ownership of the work and demonstrate an exceptional work ethic towards discovering breakthrough medicines that will improve patients’ lives.

What we are looking for

Essential Experience/Skills
  • PhD level qualification or MSc and equivalent experience in a relevant biological science
  • Experience and proven track-record of developing NGS-based and/or omics assays
  • Demonstrable technical expertise in basic molecular biology techniques
  • Strong leadership skills and a track record in contributing directly to the delivery of projects and objectives in defined timelines
  • Proven experience of leading and managing scientific teams in industry
  • Experience of building and managing teams, recruitment, personal development, and performance management
  • Ability to design research project plans including short-term and long-term experimental plans, needs assessment, prioritise follow-up studies (timelines, costs, deliverables)
  • Ability to design and run experiments, interpret data, troubleshoot, and suggest next steps and identify alternative approaches
  • Ability to develop and improve new skills and knowledge necessary to successfully support assigned projects
  • Excellent communication, organisational and leadership skills, with a successful track record of collaborating with cross-functional, matrix teams
  • Strong organisational and time management skills; ability to work on multiple projects simultaneously, as well as ability to prioritise and balance competing demands
  • A positive “can-do” and result oriented attitude, with openness to new ideas and ability to work flexibly in a highly dynamics environment
Preferred experience
  • Direct personal experience of leading genomic or molecular biology-based projects within a fast growing biotech
  • Experience in pharmaceutical/biotech industry
  • Track record of working with genomics assays and data that map open chromatin, transcriptome, genome, epigenetics marks and 3D genome interactions
  • An enthusiasm for and demonstrable knowledge of the key questions and recent developments in gene regulation, genomics methods and/or the genomics field
  • An understanding of immune disease biology and the principles of early drug discovery
To apply please send us your CV at [email protected]. If you know someone who could be a good fit, please share this posting with them.
Apply now

At Nucleome Therapeutics equality, diversity and inclusion is really important to us. We welcome applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status.