Unlock understanding of the regulatory genome to advance the next generation of personalised medicines with unprecedented speed, scale and precision.
Nucleome was founded in 2019 by leading experts in gene regulation at the University of Oxford, using state of the art, proprietary genomics approaches to decipher disease biology.
The Company fuses computational and biological expertise to understand how genes are regulated and interact in a dynamic multidimensional context.
Approach
Nucleome identifies how human genetic variation effects certain cells and how those changes regulate gene function. In taking this approach Nucleome aims to address one of the biggest questions in drug discovery and development – how does genotype result in phenotype, and what goes wrong in biology to cause disease?
Through its own pipeline activity, and via pharmaceutical company collaborations, the unique insight generated by Nucleome is used to:
Nucleome’s approach can be applied to multiple disease indications and cell types. The initial focus is on inflammatory conditions, particularly rheumatoid arthritis, lupus, inflammatory bowel disease and multiple sclerosis.
Nucleome is backed by world-class investors
Including M Ventures, the strategic corporate venture capital arm of Merck KGaA; Johnson and Johnson Innovation-JJDC, Inc. (“JJDC”), the strategic venture capital arm of Johnson & Johnson; Pfizer Ventures, the venture group of Pfizer; British Patient Capital; and founding investor Oxford Science Enterprises.
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