Company

Advancing the understanding of the genetic basis of human disease

Mission

Unlock understanding of the regulatory genome to advance the next generation of personalised medicines  with unprecedented speed, scale and precision.  

About Nucleome

Nucleome was founded in 2019 by leading experts in gene regulation at the University of Oxford, using state of the art, proprietary genomics approaches to decipher disease biology.
The Company fuses computational and biological expertise to understand how genes are regulated and interact in a dynamic multidimensional context. 

Approach

Nucleome identifies how human genetic variation effects certain cells and how those changes regulate gene function. In taking this approach Nucleome aims to address one of the biggest questions in drug discovery and development – how does genotype result in phenotype, and what goes wrong in biology to cause disease?
 
Through its own pipeline activity, and via pharmaceutical company collaborations, the unique insight generated by Nucleome is used to:

Elucidate the mechanistic basis 
for disease and the relationships 
to patient subgroups
Discover novel targets for precision medicines
Improve the understanding of existing druggable targets
Stratify patients according to the molecular characteristics of their disease

Nucleome’s approach can be applied to multiple disease indications and cell types.  The initial focus is on inflammatory conditions, particularly rheumatoid arthritis, lupus, inflammatory bowel disease and multiple sclerosis.

Nucleome is backed by world-class investors

Including M Ventures, the strategic corporate venture capital arm of Merck KGaA; Johnson and Johnson Innovation-JJDC, Inc. (“JJDC”), the strategic venture capital arm of Johnson & Johnson; Pfizer Ventures, the venture group of Pfizer; British Patient Capital; and founding investor Oxford Science Enterprises.

Meet the Nucleome Team

Leadership Team
Board of Directors
Founding Team
Dr. Mark Bodmer
Chief Executive Officer
Dr. Stephen Harrison
Chief Scientific Officer
Stephanie Maley
Chief People Officer
Joanne Wagstaff
Head of Finance
Dr. Jonny Wray
Chief Technology Officer
Dr. Rana Al-Hallaq
Non-Executive Director
Dr. Bauke Anninga
Non-Executive Director
Dr. Mark Bodmer
Chief Executive Officer
Dr. John Davis
Non-Executive Director
Dr. Russell Greig
Non-Executive Chair of the Board
Dr. Jonathan Hepple
Non-Executive Director & OSE Advisor
Prof. Jim Hughes
Scientific Founder, Non-Executive Director
Emma Johnson
Non-Executive Director
Dr. Fiona MacLaughlin
Non-Executive Director
Prof. Jim Hughes
Scientific Founder, Non-Executive Director
Dr. James Davies
Academic Founder, Board Observer
Dr. Danuta Jeziorska
Scientific Founder & Former-CEO

Our Partners

Nucleome is collaborating with a major pharmaceutical company and foresees multiple opportunities to collaborate with other companies to identify targets and responsive patients in a variety of therapeutic areas.

Learn More about Joining Nucleome

If you are interested in joining Nucleome, contact us to learn more about our open positions