Nucleome has the unique ability to discover and validate first-in-class targets through genetics in the dark genome. It’s here, in the dark genome, that we find the genetic changes that impact function of regulatory switches that turn genes on and off in specific cell types – many of them located a long distance from the genes they control, making it challenging to find the connections.
DNA is dynamically organised in three dimensions, enabling genes and their switches to connect, so gene expression occurs at the right time and in the right place.
Genetic changes within these control switches affect gene activity, leading to disease.
At Nucleome we’re going deep into the uncharted territory of the dark genome in search of better treatments for some of the most complex diseases.
Our unique technology platform allows us to map the connections between genes and their switches with unprecedented resolution. We can then home in on how genetic changes in the dark genome affect gene activation, find which genes are involved, and explore the impact of these changes on biological pathways in specific cell types at scale.