News & Insights

July 2021

Dr Danuta Jeziorska, CEO and co-founder of Nucleome Therapeutics explains how the Company is Shining a light on the dark genome in MedNous, Research Strategy article

June 10 2021

Nucleome Therapeutics announces publication of a novel method enabling 3D genome mapping at single base pair resolution in the journal Nature

May 19 2021

Nucleome Therapeutics announces appointment of Dr Jonathan Hepple as a Non-Executive Director to its Board

NATURE | 2021 Jul

Defining genome architecture at base-pair resolution

Hua P, Badat M, Hanssen LLP, Hentges LD, Crump N, Downes DJ, Jeziorska DM, Oudelaar AM, Schwessinger R, Taylor S, Milne TA, Hughes JR, Higgs DR, Davies JOJ. PMID: 34108683

NATURE COMMUNICATIONS  | 2021 Jan 22

High-resolution targeted 3C interrogation of cis-regulatory element organization at genome-wide scale

Downes DJ, Beagrie RA, Gosden ME, Telenius J, Carpenter SJ, Nussbaum L, De Ornellas S, Sergeant M, Eijsbouts CQ, Schwessinger R, Kerry J, Roberts N, Shivalingam A, El-Sagheer A, Oudelaar AM, Brown T, Buckle VJ, Davies JOJ, Hughes JR. PMID: 33483495

NATURE GENETICS | 2018 Dec

Single-allele chromatin interactions identify regulatory hubs in dynamic compartmentalized domains

Oudelaar AM, Davies JOJ, Hanssen LLP, Telenius JM, Schwessinger R, Liu Y, Brown JM, Downes DJ, Chiariello AM, Bianco S, Nicodemi M, Buckle VJ, Dekker J, Higgs DR, Hughes JR. PMID: 30374068

NATURE COMMUNICATION  | 2019 Nov 27

A revised model for promoter competition based on multi-way chromatin interactions at the α-globin locus

Oudelaar AM, Harrold CL, Hanssen LLP, Telenius JM, Higgs DR, Hughes JR. PMID: 31776347

NUCLEIC ACIDS RESEARCH  | 2017 Dec 15

Robust detection of chromosomal interactions from small numbers of cells using low-input Capture-C

Oudelaar AM, Davies JOJ, Downes DJ, Higgs DR, Hughes JR. PMID: 29186505

BIO-PROTOCOL | 2017 Dec 5

Low-input Capture-C: A Chromosome Conformation Capture Assay to Analyze Chromatin Architecture in Small Numbers of Cells

Oudelaar AM, Downes DJ, Davies JOJ, Hughes JR. PMID: 29270442

NATURE METHODS | 2017 Jan 31

How best to identify chromosomal interactions: a comparison of approaches

Davies JO, Oudelaar AM, Higgs DR, Hughes JR. PMID: 28139673

NATURE METHODS  | 2015 Nov 23

Multiplexed analysis of chromosome conformation at vastly improved sensitivity

Davies JO, Telenius JM, McGowan SJ, Roberts NA, Taylor S, Higgs DR, Hughes JR. PMID: 26595209