Our research dramatically improves our understanding of how the dark genome drives diseases and has potential to discover novel high-quality targets guided by genetics across multiple diseases to build a robust pipeline of drug assets
Nucleome decodes genetic variation within the dark matter of the human genome to find new ways to treat diseases.
The dark genome makes up over 98% of our DNA which does not encode for proteins and is largely uncharted. It acts like an instruction manual that defines cell type specificity, switching genes on and off at the right time and level. This allows it to be able to translate the universal genome, present in human cells into multiple, differentiated cell types.