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Senior Scientist - Functional Genomics

COMPENSATION: Competitive with share options available

LOCATION: The Schrodinger Building, Oxford Science Park, Oxford

HOURS: Full-time


NUCLEOME THERAPEUTICS, a fast-emerging biopharma that is building a passionate, creative, and dedicated multi-disciplinary team of scientists with expertise in gene regulation, genomics, machine learning, drug discovery, data analysis and software development, whose mission is to decode and mine the regulatory “dark matter” of the human genome to transform drug target discovery and deliver first-in-class precision medicine for autoimmune diseases. We are building a rewarding and fun environment where people embrace creative ways of thinking, take smart risks, and feel empowered to make a difference.

The Role

We are seeking a highly motivated Senior Scientist with expertise in Functional Genomics who is a self-starter, proactive and would like to work in a dynamic environment of a growing biotech. The successful candidate will develop and implement cutting-edge genomics and genetic engineering techniques to discover and validate therapeutic targets by decoding the genetics located in the Dark Genome, with an initial focus on lymphocyte subsets and autoimmune diseases. You will collaborate closely with other experimental and data scientists to guide drug-target discovery efforts. As an independent thinker you will plan and implement experiments, interpret the data, and distil complexity into concise communication, while providing scientific coaching and mentorship for less experienced team members. You will have an integral role in the venture, take ownership of the work and demonstrate an exceptional work ethic towards discovering breakthrough medicines that will improve patients’ lives.

What we are looking for

Essential Experience/Skills
  • PhD in biological discipline, or MSc and demonstrable experience in the relevant field
  • Demonstrable experience in working with CRISPR/Cas9 technologies
  • Demonstrable experience in one or more of the following assays: ATAC-seq, ChIP-seq, RNA-seq and 3C based assays
  • Demonstrable understanding of major next-generation sequencing techniques and generating insights from such data
  • Familiarity with web-based interfaces for genome analysis
  • Ability to design and run high-quality experiments, interpret data, troubleshoot, and suggest next steps and identify alternative approaches
  • Ability to develop and improve new skills and knowledge necessary to successfully support assigned projects
  • Ability to work independently as well as thrive working in a multidisciplinary team
  • Strong communication skills and ability to communicate complex ideas to specialists and non-specialists
  • Flexible and co-operative approach to colleagues
  • Strong organisational and time management skills; ability to work on multiple projects simultaneously, as well as ability to prioritise and balance competing demands
  • Ability to deliver high-quality, consistent results in a timely fashion
  • A positive “can-do” and result oriented attitude, with openness to new ideas and ability to work flexibly in a highly dynamics environment
Preferred experience
  • Experience in pharmaceutical/biotech industry
  • Experience in interpreting population genomics studies e.g. GWAS
  • Experience in working with primary cell types
  • Expertise in disease biology, ideally autoimmune or other immunology-based diseases
  • Understanding of drug discovery and development processes
  • Proficiency in working in a UNIX based computational environmental
  • Ability and willingness to manage people and/or projects
  • Experience supporting and collaborating with computational scientists
  • An enthusiasm for and demonstrable knowledge of the key questions and recent developments in gene regulation, epigenetics and/or the genomics field
To apply please send us your CV at [email protected]. If you know someone who could be a good fit, please share this posting with them.
Apply now

At Nucleome Therapeutics equality, diversity and inclusion is really important to us. We welcome applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status.