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Senior Scientist - Functional Genomics

COMPENSATION: Competitive with share options available

LOCATION: The Schrodinger Building, Oxford Science Park, Oxford

HOURS: Full-time


NUCLEOME THERAPEUTICS, a fast-emerging biopharma that is decoding the dark matter of the human genome for precision medicine. The dark genome holds more than 90% of disease-linked genetic variants whose value remains untapped, representing a significant opportunity for drug discovery and development. We have the unique ability to link these variants to gene function and map disease pathways. Our cell type-specific platform creates high resolution 3D genome structure maps and enables variant functional validation at scale in primary cell types. This enables us to discover and develop novel, better and safer drugs.

Nucleome Therapeutics was founded by leading experts in gene regulation from the University of Oxford and backed by investment from Oxford Sciences Enterprises.

The Role

At Nucleome Therapeutics, we are building a passionate, creative and dedicated multi-disciplinary team of scientists on a mission to decode the dark genome to bring precision medicine to patients. We are building a rewarding and fun environment where people embrace creative ways of thinking, take smart risks, and feel empowered to make a difference. If you want to be an integral part of our team on this journey.

We are seeking a Senior Scientist with expertise in Genomics who is a self-starter, proactive and would like to work in a dynamic environment of a start-up. The successful candidate will investigate the regulation of the non-coding genome in lymphocyte subsets (initially) using state of the art genomics approaches whilst also developing new ones. You will collaborate closely with other experimental and data scientists to guide drug target discovery efforts through interpretation of the Dark Genome’s genetics. As an independent thinker you will plan and implement experiments, interpret the data, and distil complexity into concise communication, while providing scientific coaching and mentorship for less experienced team members. You will have an integral role in the venture, take ownership of the work and demonstrate an exceptional work ethic towards discovering breakthrough medicines that will improve patients’ lives.

What we are looking for

Essential Experience/Skills
  • PhD in biological discipline, or MSc and demonstrable experience in the fields above.
  • Demonstrable experience in one or more of the following assays: ATAC-seq, ChIP-seq, RNA-seq and 3C based assays.
  • Experience and proven-track record in interpreting and generating insights from omics data
  • Demonstrable technical expertise in basic molecular biology techniques.
  • Familiarity with web-based interfaces for genome analysis.
  • An enthusiasm for and demonstrable knowledge of the key questions and recent developments in gene regulation, epigenetics and the genomics field.
  • Ability to design research project plans including short-term and long-term experimental plans, needs assessment, prioritise follow-up studies (timelines, costs, deliverables).
  • Ability to design and run high-quality experiments, interpret data, troubleshoot, and suggest next steps and identify alternative approaches.
  • Ability to develop and improve new skills and knowledge necessary to successfully support assigned projects
  • Proven ability to set up and optimise complex molecular techniques.
  • Ability to work independently as well as thrive working in a multidisciplinary team.
  • Strong communication skills and ability to communicate complex ideas to specialists and non-specialists.
  • Flexible and co-operative approach to colleagues.
  • Strong organisational and time management skills; ability to work on multiple projects simultaneously, as well as ability to prioritise and balance competing demands.
  • Ability to deliver high-quality, consistent results in a timely fashion.
  • A positive “can-do” and result oriented attitude, with openness to new ideas and ability to work flexibly in a highly dynamics environment.
Preferred experience
  • Experience in pharmaceutical/biotech industry.
  • Experience in working with primary cell types
  • Expertise in disease biology, ideally autoimmune or other immunology-based diseases
  • Experience in interpreting population genomics studies e.g. GWAS
  • Understanding of drug discovery and development processes.
  • Proficiency in working in a UNIX based computational environmental.
  • Ability and willingness to manage people and projects.
  • Experience supporting and collaborating with computational scientists.
  • Knowledge and experience in GLP standards.
To apply please send us your CV at [email protected]. If you know someone who could be a good fit, please share this posting with them.
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At Nucleome Therapeutics equality, diversity and inclusion is really important to us. We welcome applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status.